Cytotoxic Activity of Triazole-Containing Alkyl β-D-Glucopyranosides on a Human T-Cell Leukemia Cell Line

E. Davis Oldham, University of Mary Washington
Larissa M. Nunes
Armando Varela-Ramirez
Stephen E. Rankin
Barbara L. Knutson
Renato J. Aguilera
Hans-Joachim Lehmler

Abstract

Simple glycoside surfactants represent a class of chemicals that are produced from renewable raw materials. They are considered to be environmentally safe and, therefore, are increasingly used as pharmaceuticals, detergents, and personal care products. Although they display low to moderate toxicity in cells in culture, the underlying mechanisms of surfactant-mediated cytotoxicity are poorly investigated.